Next, immunocompetent and immunodeficient mice were injected separately and subcutaneously with pancreatic cancer cells pretreated with DMSO or a USP8-specific inhibitor (1 μM, 24 h), to further assess the impact of inhibiting USP8 on pancreatic cancer tumorigenesis and development (Fig. 2k). Here, USP8 is linked to pancreatic neoplasm.