In immunocompetent C57Bl/6 J mice, tumors formed by Usp8 KD cells (5 ×105) showed decreased tumor size and weight relative to those induced by parental KPC cells (5 ×105); however, this effect was not observed when the experiment was repeated using Nude (immunodeficient) mice (Fig. 2a–f). The gene discussed is USP8; the disease is neoplasm.