USP8 and pancreatic neoplasm: As expected, high levels of USP8 were detected in human pancreatic cancer cell lines (BxPC-3, CFPAC-1, T3M4, MIA PaCa-2, SW1990, and PANC-1) and the mouse pancreatic cancer cell line (KPC), but not in Panc02; no USP8 was detected in HPNE cells (normal pancreatic ductal cells) (Fig. 1i).