USP8 and pancreatic neoplasm: Similarly, immunofluorescence analysis and fluorescence intensity plots showed significant USP8/PD-L1 colocalization (USP8: red; PD-L1: green) in KPC cells, BxPC-3 cells, KPC mouse pancreatic tumor tissues, and human pancreatic tumor tissues (Fig. 3i–l; Fig. S6a–d).