CD8A and neoplasm: By contrast, Hodges et al. concluded no association between tumor mutational burden (TMB) and T-cell infiltration based on IHC for PD-1, PD-L1 and CD8 in human GBMs21; however, while the cohort sizes interrogated for PD-1 and PD-L1 were sizable according to Hodges et al. (n = 94 and 189, respectively) the cohort interrogated for CD8 (n = 9) was less so and other pan-T-cell markers were not considered.