APOE and heart disorder: In both HFD-induced obese mice and high-fat high-cholesterol diet (HFHCD)-fed induced hypercholesterolemic apoE−/− mice, FT3 and LT3 modestly decreased serum levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), as well as cholesterol ratio (TC/high-density lipoprotein cholesterol), the latter which of is regarded as a better indicator for heart disease (Fig. 7a–d).