Treatment of lipodystrophic mice with the same dose of PLT3 as used in dietary obese mice had no significant effects on body weight, whole-body energy expenditure, glucose intolerance, serum insulin, fatty liver, and serum TC as compared to vehicle-treated mice (Supplementary Fig. 9), suggesting that adipose tissue is obligatory for mediating the systemic effects of PLT3 on glucose/lipid metabolism and insulin sensitivity. Here, INS is linked to Glucose intolerance.