Furthermore, when we analyzed their transcriptomic profile (Supplementary Fig. 3g–j), ccRCC cells grown in Plasmax displayed the activation of transcription factors (TF) such as Hypoxia-inducible Factor 2A (HIF2A, EPAS1 gene), MYC Associated Factor X (MAX), and Paired Box 8 (PAX8), known drivers of ccRCC20,27,28 (Supplementary Fig. 2b). Here, EPAS1 is linked to nonpapillary renal cell carcinoma.