Finally, the uptake of BCAAs was not significantly different among the cells types, with the exception of valine in 786-O and 786-M1A cells (Supplementary Fig. 2g), even though the heterodimer transport system between the Solute Carrier Family 7 Member 5 (SLC7A5, LAT1) and Solute Carrier Family 3 Member 2 (SLC3A2, CD98) (Supplementary Fig. 2h) was upregulated in all ccRCC cells compared to HK2 cells. This evidence concerns the gene SLC7A5 and nonpapillary renal cell carcinoma.