We also examined the effects of SeC on the mRNA levels of Nrf2 (NFE2L2), KEAP1, NQO1, SQSTM1, and SLC7A11 in Nrf2-addicted CRC cells (Supplementary Fig. 3A, B) and non-Nrf2-addicted MSCs (Supplementary Fig. 3C) after 6, 12, or 24 h treatment. The gene discussed is SQSTM1; the disease is colorectal carcinoma.