Brd4-mediated optimal NLRC4 inflammasome activation is critical in host innate immunity against Salmonella infections since Brd4-deficient BMDMs displayed reduced IL-1β and IL-18 expression and Brd4-conditional knockout mice exhibited increased bacterial loads in various tissues and mortality upon S. typhimurium infection [31]. The gene discussed is BRD4; the disease is Salmonella Infections.