Furthermore, by comparing the transcriptome program of the ICD-based DC vaccine with the transcriptome data from the TCGA-LGG patients, we identified a four-gene signature (CFH, GALNT3, SMC4, and VAV3) that is strongly associated with overall survival of glioma patients, and we validated it on the CGGA-LGG, TCGA-GBM, and CGGA-GBM datasets (Fig. 8). The gene discussed is SMC4; the disease is glioblastoma.