Comparison of the transcriptome program of the DC vaccines loaded with GL261 cells undergoing ICD after PS-PDT with the transcriptome data from The Cancer Genome Atlas (TCGA-LGG) dataset identified a four-gene signature (CFH, GALNT3, SMC4, and VAV3) associated with overall survival of glioma patients. This evidence concerns the gene GALNT3 and central nervous system cancer.