The protective role of β-catenin against tubular apoptosis and necroptosis was confirmed in septic AKI induced by LPS in which apoptosis and overexpression of p-MLKL and p-RIP3 were ameliorated in TubCat mice but exacerbated in TubCatKO mice (Fig. 4A–D). This evidence concerns the gene MLKL and acute kidney injury.