For example, another study concluded that the POT1 p.Ala532Pro variant shows impaired ACD binding, which may also lead to telomere dysregulation.19 Therefore, further systematic experiments are needed to address other POT1 functions, such as telomere fragility, to provide a more complete catalogue of variants that alter protein function and therefore that lead to cancer predisposition. The gene discussed is POT1; the disease is cancer.