Notably, depletion of CUL4B or MTA1 in CXXC5-overexpressing tumors led to a diminished effect of CXXC5 overexpression; consistently, the decrease in tumor growth associated with CXXC5 knockdown could be rescued by the simultaneous silencing of TSC1 (Fig. 5D). This evidence concerns the gene CXXC5 and neoplasm.