This same mitfa promoter fragment has been widely utilized in modifier screens on top of BRAFV600E to drive expression of novel melanoma oncogenes such as SETDB1 (Ceol et al., 2011), SOX10 (Kaufman et al., 2016), and GDF6 (Venkatesan et al., 2018) in melanocytes. The gene discussed is MITF; the disease is melanoma.