CAMK2A and Crouzon syndrome-acanthosis nigricans syndrome: In this case, a brain-specific (particularly forebrain) transgenic Cre line, e.g. calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα)-Cre, can be implemented in concert with functional assays to ascertain whether HRV abnormality associated with specific genes is secondary to CAN dysfunction.