Indeed, it remains unclear whether the mechanisms of systemic “long-haul” COVID-19 infection, which have been attributed viral persistence in ACE2-expressing organ systems, autoimmunity due to cryptic antigens and viral mimicry, and persistent inflammation due to the altered cytokine environment and persistence of pro-inflammatory immune cells, can explain the persistence of ocular symptoms [29]. This evidence concerns the gene ACE2 and Autoimmunity.