MAPT and amyloidosis: High synaptic activity induces perisynaptic release of tau and Aβ proteins [16, 70, 95], and although the role of tau oligomers in neuronal excitability is still a matter of continuous investigation [37], soluble oligomeric forms of Aβ increase synaptic activity [12, 102], suggesting that a positive feedback loop between hyperexcitability and amyloidosis may first compromise neuronal function and then lead to neurodegeneration.