GPHN and Alzheimer disease: Additionally, we did not find differences in the total number of labeled PSD95 or gephyrin-immunolabeled synaptosomes in the hippocampus, even though marked reductions in the total number of synapses have been reported for AD and MCI in CA1 using transmission electron microscopy [61] and in the CA1 and CA3 stratum pyramidale by immunofluorescence [25].