Some of them were already known to play a role in AD: PICK1 is involved in synaptic scaling [3]; AP2A2 is involved in receptor-mediated endocytosis [60]; SYT7 is regulated by amyloid precursor protein [5]; and KIF5B is critical for GABAAR transport, and its deletion causes epilepsy [58]. This evidence concerns the gene AP2A2 and Alzheimer disease.