ADA and infection: The genes which have closer association with NTDs, like MTHFR, ALDH1A2, ADA, and MTR, all belong to folic acid in the metabolic pathway enzyme gene, MFTC(SLC25A32) belongs to transport protein gene, ARID1A coding is a transcription factor, PRICKLE belongs to genes related to embryo development, and FUT2 is associated with the immune processing of post pathogen infection [13].