IFNA1 and dermatomyositis: Considering that dermatomyositis is associated with sustained inflammation characterized by high levels of IFN-I [126], the authors performed loss- and gain-of-function experiments to demonstrate that high levels of IFN-I decrease the proliferation of MuSCs, while pharmacological inhibition of IFN signaling rescued the proliferation of MuSCs from dermatomyositis patients [129].