MYOD1 and chronic obstructive pulmonary disease: In a mice model of inducible IL-13-driven pulmonary emphysema (IL-13TG), that mimics many of the features of COPD, it was shown that there is a reduction in the replication rate and in mRNA expression of MyoD, Myf5, and Myh3 (embryonic myosin heavy chain) in MuSCs cultured in vitro [48].