Subsequently, CRC cells transfected with sh‐nc, shIGFL2‐AS1#1, pCDH, and oe IGFL2‐AS1 were incubated with the same concentration of MG132 for 6 h, and western blotting was used to measure the change in HIF‐1α protein level. This evidence concerns the gene IGFL2 and colorectal carcinoma.