For instance, a PEG-b-PBD polymersome (Scheme 5) decorated with a biomimetic targeting peptide, PR_b, (sequence: KSSPHSRN(SG)5RGDSP) has been described for the delivery of the apoptosis-inducing protein tumour necrosis factor alpha (TNF-α) to human prostate cancer cells (LNCaP).399 This PR_b peptide resembles the cell adhesion binding site and also features a specific amino acid sequence which, as a synergistic secondary binding site to integrins, allows to better mimic the cell surface-matrix adhesion. This evidence concerns the gene TNF and prostate cancer.