A self-cross-linked reduction-responsive polymersome formulation based on PEG-b-poly(N-2-hydroxypropyl methacrylamide-g-lipoic acid)-b-poly(acrylic acid) (PEG-b-P(HPMA-co-LA)-b-PAA; Scheme 12), functionalised with anisamide and encapsulating granzyme B, was tested in vivo with mice bearing human lung xenografts.422 The functionalised polymersomes were observed to deliver the model protein cytochrome C more efficiently into the tumour cells compared to non-functionalised polymersomes. This evidence concerns the gene GZMB and neoplasm.