In this study, by establishing AS mouse model and using hVSMC as a cell model, we demonstrated that puerarin can improve the symptoms of atherosclerosis in mice, inhibit the proliferation and migration of hVSMC, promote its apoptosis, and inhibit the levels of inflammatory cytokines IL-6 and IL-8 in mice and hVSMC. Here, CXCL8 is linked to atherosclerosis.