CHD8 and schizophrenia: Specifically, experimental validation at the ITSN1 locus, the Intersectin 1 gene involved in endocytic membrane traffic and synaptic transmission (77,78), complex learning and memory formation (79) as well as previously implicated in schizophrenia (80), confirmed a clear reduction in H3K36me3 enrichment and a corresponding increase in the PSI ratio (spliced in/spliced in + spliced out) of the splicing variants in hNPCs presenting knockdown levels of CHD8 (Figure 3F–I).