CHD8 and atrial fibrillation: Notably, once again, AF, the most affected AS subtype by CHD8 suppression, was revealed to be the most recurrent aberrant AS event type after hnRNPL reduction (Figure 5E), while pathways and GO terms associated with ‘nuclear-transcribed mRNA’ and ‘RNA catabolic process’ were recurrently enriched in the lists of genes affected by dysfunctional splicing in both CHD8 and hnRNPL suppression data (Figure 5F).