Sam68 is also an oncogene (10,11): high expression of Sam68 correlates with poor prognosis in many cancers, including prostate and colon cancers (12,13), while depletion of Sam68 decreases cell migration in HeLa cells (14), and inhibits proliferation and tumour progression in prostate and breast cancers (12,15). Here, KHDRBS1 is linked to colonic neoplasm.