Other gain of function mutations seen in CTCL include Nav3 (12q21), JunB (chr19), c-MYC/MAX, p53, PTEN/Fas, p15, p16, NFKB, bcl-2, and Stat2.The mutations in CTCL are still being studies and as of now there are more than 500 chromosomal abnormalities, including TCR signalling and chromatin modification, noted in CTCL. This evidence concerns the gene PTEN and primary cutaneous T-cell non-Hodgkin lymphoma.