We also clarified the stimulatory impact of METTL3 on ICAM2 level in RA‐FLSs and discovered the inhibitory effect of ATT on METTL3‐mediated m6A modification of ICAM2 mRNA in RA‐FLSs, emphasising the regulated impact of m6A RNA methylation on the antirheumatic activity of ATT. The gene discussed is METTL3; the disease is rheumatoid arthritis.