To further confirm whether ICAM2 affected the PI3K/AKT/p300 pathway, we knocked down ICAM2 in RA‐FLSs and found that p‐PI3K, p‐AKT and p300 levels were downregulated in ICAM2‐deficient RA‐FLSs (Figure 6O–Q). This evidence concerns the gene ICAM2 and rheumatoid arthritis.