More importantly, we also confirmed that ATT has therapeutic potential for RA management by suppressing proliferation, migration and invasion, and inducing apoptosis in RA‐FLSs by modulating METTL3/ICAM2/PI3K/AKT/p300 feedback loop, supplying the foundation for the clinical application of ATT in RA therapy. Moreover, METTL3, ICAM2 and p300 might serve as biomarkers for the therapy response of RA patients. The gene discussed is EP300; the disease is rheumatoid arthritis.