demonstrated that the Gdpd3 gene, which encodes the lysophospholipase D enzyme, is more highly expressed in murine CML stem cells compared with wild‐type HSCs, and that Gdpd3‐deficient CML stem cells have impaired self‐renewal capabilities.84, 85. Here, GDPD3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.