Moreover, by classifying patients into previously described ccRCC evolutionary subtypes (Additional file 2: Fig. S3), we observed that PBRM1-driven tumors were enriched in the ITH-high cluster (on sample level, Fisher exact test P = 0.0018), in agreement with TRACERx Renal [15]. The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.