For both phase-1 and phase-2 pigs, six common pathways were enriched in the immune system, such as asthma, rheumatoid arthritis, the intestinal immune network for IgA production, allograft rejection, autoimmune thyroid disease, and systemic lupus erythematosus (Fig. 3c, Supplemental Table S3). Here, CD79A is linked to rheumatoid arthritis.