CD33 (also known as Siglec-3) [80], is one of the several microglial-specific genes that have been linked to AD susceptibility via genome-wide association studies (GWAS) [81] and both mediate immune suppression by binding sialoglycan targets and attenuates phagocytosis by microglia during AD progression [80, 82]. The gene discussed is CD33; the disease is Alzheimer disease.