MAPT and Alzheimer disease: We next generated snRNA-Seq dataset from the human superior frontal gyrus (SFG) at Braak stage 2, which is devoid of tau pathology, and entorhinal cortex (ERC) at Braak stage 2, where AD pathology is first detected and shares a pathological resemblance to our 6-month-old Tau4RΔK-AP mice (Fig. 5A-C).