Siglecs, in particular Siglec10, are AD-enriched, as the level of Siglec-10 + cells in non-AD tauopathy was similar to that of control and low Braak stage AD (Figs. 6F, S16), indicating that Siglec-10 could potentially serve as an AD biomarker and a potential therapeutic target associated with late-stage AD. The gene discussed is SIGLEC10; the disease is Alzheimer disease.