MAPT and amyloidosis: These broad LADAM marker-expressing microglia (Cd74 and MHC Class II genes) have been previously shown in some amyloidosis mouse models at late stages (known as activated response microglia) [48–50], but these genes are likely to be contributed by mild tau phosphorylation shown in these amyloidosis mouse models, based on our findings from Tau4RΔK (Fig. 2).