For these two time points, in addition to Tau4RΔK-AP mice, we also collected cerebral cortices and hippocampi from littermate controls (WT), APP;PS1 (Aβ plaques (S1)), and Tau4RΔK (tau deposition, neuronal loss (Figure S1), and brain atrophy (Figure S1)) mice. Here, PSEN1 is linked to Brain atrophy.