MAPT and Alzheimer disease: Tau4RΔK-AP mice faithfully model not only the development of canonical AD pathologies, including the pathological conversion of wild-type mouse tau [24], but also the disease stage-specific emergence of EADAM and LADAM in response to both Aβ plaques and tau deposition, emphasizing that our mouse model will prove useful in both analyzing AD disease mechanisms and testing therapeutic strategies for treating AD.