These broad LADAM marker-expressing microglia (Cd74 and MHC Class II genes) have been previously shown in some amyloidosis mouse models at late stages (known as activated response microglia) [48–50], but these genes are likely to be contributed by mild tau phosphorylation shown in these amyloidosis mouse models, based on our findings from Tau4RΔK (Fig. 2). This evidence concerns the gene CD74 and amyloidosis.