Although LADAM was observed in Tau4RΔK-AP,Tau4RΔK, and APP;PS1 samples, we found that many LADAM-specific genes (e.g. MHC Class II genes) are more highly expressed in Tau4RΔK than in APP;PS1 microglia (Fig. 2G), suggesting that this microglia subtype might be induced by the development of tauopathies, such as tau tangles or tau phosphorylation. Here, PSEN1 is linked to tauopathy.