CD74 and amyloidosis: However, since MHC class II genes that are expressed in LADAM, such as Cd74, H2-A2, H2-Eb1, and H2-Ab1, have also been previously observed in microglia in both the CK-p25 neurodegeneration mouse model [52, 53] and some mouse models of late-stage amyloidosis [48–50], some of LADAM gene modules may be induced at least in part by neuronal death.