During early-stage disease in 6-month-old Tau4RΔK-AP, but not APP;PS1 or Tau4RΔK mice, the presence of both Aβ and tau pathologies induced a novel microglia subtype we termed Early-stage AD-Associated Microglia (EADAM), which is distinct from DAM and express multiple interferon-regulated genes. Here, MAPT is linked to Alzheimer disease.