The fact that EADAM are first detected in 6-month-old Tau4RΔK-AP mice and Braak stage II AD datasets, while LADAM are first detected in 12-month-old Tau4RΔK-AP mice and Braak stage IV AD datasets, demonstrates that disease stage-dependent changes in microglial subtypes in mice with Aβ and tau pathologies mimic those seen in AD. Here, MAPT is linked to Alzheimer disease.