The CD14+ monocytes in the MS samples were characterized by an upregulation of genes associated with phagocytosis and lipid metabolism like LPL, APOE, and AXL [35], an observation reminiscent of the phenotypes displayed by microglia at the rims of the chronic active lesions [36, 37] (Fig. 4E). This evidence concerns the gene APOE and myeloid sarcoma.