Further, adding a miR-19b-3p mimic after circNTNG1 overexpression reversed the change of HOXA5 and Slug protein expression (Fig. 8A, C and Additional file 5: Fig. S5F), as well as the migration and invasion phenotype of RCC cells (Fig. 8B, D and Additional file 5: Fig. S5G). This evidence concerns the gene HOXA5 and renal cell carcinoma.