Next, to examine the relationship between HNRNPC and tumor microenvironment, IF was analyzed in tumor xenografts and the representative staining images of DAPI, CD4, CD8, CD31 and collagen I were shown in Fig. 7D. The results revealed that the fluorescence density of CD8 was significantly increased after HNRNPC knockdown. The gene discussed is CD8A; the disease is neoplasm.