CD1C and Langerhans cell histiocytosis: In the peripheral blood of LCH patients, the BRAFV600E mutation was detectable in CD11c+CD1c+ dendritic cells, CD14+ classic monocytes and CD14−CD16+ non-classic monocytes almost exclusively in patients with MS disease, correlating with high-risk and active disease, but could not be detected in unfractionated peripheral blood mononuclear cells (PBMCs) from SS-LCH patients [49, 61, 62].