As expected, compared with CD4+ T cells transfected with the blank plasmid, the SUV39H1 protein expression (Fig. 5a, b), SUV39H1 (Fig. 5c) and H3K9me3 (Fig. 5d) enrichments in the CREMα promoter region of SLE CD4+ T cells transfected with the SUV39H1-overexpressing plasmid all strikingly upgraded, and the CREMα protein concentrations greatly alleviated (Fig. 5a, b). Here, SUV39H1 is linked to systemic lupus erythematosus.