The levels of SUV39H1 and SUV39H2 in the CREMα promoter region of CD4+ T cells from the aforementioned normal controls and patients with SLE were assessed using ChIP combined with qPCR to find the reason for the decrease in the H3K9me3 enrichment at the CREMα promoter of SLE CD4+ T cells. This evidence concerns the gene SUV39H2 and systemic lupus erythematosus.