Studies confirm that the numbers of DNA methylation at the CREMα promoter of SLE total T cells and DNMT3a in the CREMα promoter region of SLE CD4+ T cells both down-regulate, and the quantities of H3K4me3 and Set1 within this region of SLE CD4+ T cells increase [2, 37]. The gene discussed is DNMT3A; the disease is systemic lupus erythematosus.