IL17A and systemic lupus erythematosus: As a pro-inflammatory factor, IL-17A leads to a wide range of inflammatory reactions, for instance, inducing various inflammatory mediators; recruiting monocytes, neutrophils, and T cells to invade target organs (such as kidney, blood vessels, skin, etc.); promoting the proliferation of B cells and production of antibodies (including total IgG, anti-DNA antibody, and anti-histone antibody), at last leading to tissue damage and disease development in SLE patients [52, 56, 57].