CD4 and systemic lupus erythematosus: The DNA methylation enrichment at the CREMα promoter of total T cells from SLE patients has been proved to be sharply lowered [2], and DNA methyltransferase 3a (DNMT3a) within the CREMα promoter region of SLE CD4+ T cells is greatly attenuated, while the H3K4me3 and SET domain containing 1 (Set1, an important H3K4 methyltransferase) bindings in this region are strikingly elevated [37].