Moreover, the SUV39H1 binding in the CREMα promoter region of SLE CD4+ T cells significantly positively correlated with the H3K9me3 enrichment (Fig. 2c) and negatively correlated with the mRNA level of CREMα (Fig. 2d) and SLEDAI (Fig. 2e). The gene discussed is CD4; the disease is systemic lupus erythematosus.