In line with the previous report [37], the Set1 enrichment at the CREMα promoter was remarkably higher in SLE CD4+ T cells than normal controls (Fig. 8a), and the Set1 enrichment was significantly positively correlated with the CREMα mRNA level in CD4+ T cells from SLE patients (Fig. 8b). Here, SETD1A is linked to systemic lupus erythematosus.