SETD1A and systemic lupus erythematosus: Our research detects the CREMα quantity at the level of CD4+ T cells, reveals the role that SUV39H1 plays in CREMα regulation, and elucidates the correlations between SUV39H1-H3K9me3, Set1-H3K4me3, and DNMT3a-DNA methylation at the CREMα promoter of SLE CD4+ T cells for the first time ever.