CD4 and systemic lupus erythematosus: Based on this, the H3K9me3 number in the CREMα promoter region of SLE CD4+ T cells was further examined by ChIP combined with qPCR, and it was first confirmed the H3K9me3 amount at the CREMα promoter was significantly lower in SLE CD4+ T cells compared to normal controls, and the H3K9me3 quantity negatively correlated with the CREMα expression and SLEDAI of SLE patients.