The dysregulation of glycolysis not only provided tumor cells with nutrients and ATP to meet tumor proliferation and growth, but also remodeled an acidic environment that results in demolition of extracellular matrix and expedites growth and metastasis [9, 10], which was attributed to increased critical glycolytic enzymes expression, including glucose transporter isoform 1 (GLUT1), hexokinase 2 (HK2), Phosphofructokinase, platelet (PFKP), Pyruvate kinase isozymes (PKM), Lactate dehydrogenase A (LDHA), in a serial of human tumors. Here, HK2 is linked to neoplasm.