Six variants were found to be associated with doxorubicin-induced cardiotoxicity in a cohort containing osteosarcoma patients and were replicated minimally once in an independent patient cohort, namely CELF4 rs1786814, HAS3 rs2232228, RARG rs2229774, SLC22A17 rs4982753, SLC22A7 rs4149178, SLC28A3 rs7853758. The gene discussed is RARG; the disease is osteosarcoma.