The patient cohort of Koster et al. consisted of European and Brazilian subjects and they did not identify statistically significant associations with common variants in IL33. Differences in linkage disequilibrium structures between populations allowed for different variants on the same locus to be associated to survival of patients with osteosarcoma, indicating that not GLDC, but IL33 is causal for decreased survival through the variant. The gene discussed is GLDC; the disease is osteosarcoma.