CD274 and neoplasm: Patients in the high-risk group in the prognostic signature had significantly higher levels of PD-L1 mRNA expression; TMB, MSI, and SNV neoantigen; and lower levels of TIDE scores and T cell dysfunction scores, suggesting that tumors in the high-risk group are highly immunogenic and can activate immune cells to recognize tumors, but high PD-L1 expression induces suppression of anti-tumor immunity in high-risk group patients.