, who firstly reported the application of CSF RT-QuIC in prion disease diagnostics using rec PrP with the full-length (FL) human sequence, reported a sensitivity of more than 80% and a specificity of 100% in a cohort of 18 CJD patients and 30 controls (Atarashi et al. 2011). Here, PRNP is linked to Creutzfeldt Jacob disease.