Consistent with our hypothesis, HFr promoted significant AS changes in LWT mice and LΔRbfox2 mice failed to induce obesity-specific AS events at Pla2g6 (Extended Data Fig. 6a), Scarb1 (Extended Data Fig. 6b) and Numb (Extended Data Fig. 6c). This evidence concerns the gene SCARB1 and obesity due to melanocortin 4 receptor deficiency.