NUMB and obesity due to melanocortin 4 receptor deficiency: Consistent with our hypothesis, HFr promoted significant AS changes in LWT mice and LΔRbfox2 mice failed to induce obesity-specific AS events at Pla2g6 (Extended Data Fig. 6a), Scarb1 (Extended Data Fig. 6b) and Numb (Extended Data Fig. 6c).