We profiled many individual markers previously associated with HIV infection, including PD-1 (ref. 34), CXCR5 (ref. 34), CCR6 (ref. 41), CTLA-4 (ref. 42), CD69 (ref. 43), OX40 (ref. 44), CD2 (ref. 45), Lag-3 (ref. 19), TIGIT18,19, CD20 (ref. 46) and CD161 (ref. 47). This evidence concerns the gene TNFRSF4 and HIV infectious disease.