Functional enrichment analysis showed that the 9 hub genes were mainly concentrated in biological processes (BP), namely positive regulation of defense response, immune response-regulating signaling pathway, positive regulation of interleukin-6 production and cell activation, as well as two KEGG that are Osteoclast differentiation and Yersinia infection (Fig. 5A–C, Table 5). Here, IL6 is linked to Yersinia infectious disease.