SRSF1 and neoplasm: These results are in agreement with the recently reported analysis of the CRISPR screen data in the DepMap [43, 44] (Avana library public 18Q448), which shows MM cell lines to be the most sensitive tumor cell type across >400 cancer cell lines to genetic ablation of core components of the U1-U2 spliceosome including SRSF1 [17].