RAG2 and Dravet syndrome: Similar to the characteristics of HSCs in DS, our zebrafish model exhibited increased expression of the hematopoietic progenitor marker scl; the erythroid progenitor marker gata1 at the 8-somite stage during primitive hematopoiesis; significantly increased the expression level of the hematopoietic stem-cell markers runx1 at 28 hpf and cmyb at 48 hpf during definitive hematopoiesis and reduced expression levels of the T lymphocyte markers rag1 and rag2 at 4 dpf (Extended Data Fig. 4).