Notably, DMCs that showed the highest delta β values (>20%) were associated with genes that were newly related to T2D (TRANK1, TEX2, SH2D3C, ATAD1, ANKEF1, MIR138-2, OR10A5, SIM1, PRRC2C, TECRL, ZDHHC14, PHTF1, C11orf66, SH3TC2, MRGPRX1, RNF212, and FLJ16171) or previously related to T2D (FSD1L, NSF, SLIT3, PTPRN2, PSMD10, MAD1L1, MIR572, ATM, LCLAT1, and TNFRSF8) (Supplementary Table S13). The gene discussed is RNF212; the disease is type 2 diabetes mellitus.