Even though their alteration has not been well documented in T2D, some of them have been involved in T2D-related processes such as mitochondrial quality control (ATAD1), lipid metabolism (TEX2 and TECRL), inflammation (TRANK1) and stress granule assembly (PRRC2C), as well as neuronal cells development in the hypothalamus (SIM1). Here, SIM1 is linked to type 2 diabetes mellitus.