Our findings are of particular interest in light of the recent study by Rasool et al. demonstrating that phosphorylation of MED1 at T1457 upon androgen stimulation is essential for AR-mediated transcription in PCa cells, i.e. the transcription of AR targets genes (e.g. KLK3, TMPRSS2) and oncogenic drivers (e.g. ERG and MYC) (7). Here, MYC is linked to posterior cortical atrophy.