The effect of MED1 silencing on foci formation was mirrored by a lower AR transcriptional activity as seen by the reduced mRNA levels of AR-targeted genes KLK3, FKBP5 and TMPRSS2 (Figure 5I), genes that have been found within 100 kb of SE peaks in PCa cells (7). The gene discussed is MED1; the disease is posterior cortical atrophy.