Most recently, it has been revealed that the coactivator MED1 engages AR in androgen-dependent PCa cells at super-enhancer (SE) sites (7), which are clusters of enhancers enriched with RNA polymerase II (RNA POLII), p300 and H3K27ac to cooperatively assemble the transcriptional apparatus at high density and induce robust expression of key genes involved in cell identity (8,9). The gene discussed is AR; the disease is posterior cortical atrophy.