IL33 and nervous system disorder: Interleukin-33 participates in Th2-associated immune reactions.37It is expressed in specific regions of the brain and the spinal cord and mediates the interaction between immune, endothelial and CNS resident cells.38Interleukin-33 is activate inflammatory cells, including glial cells also it is involved in the neuroinflammation of many neurological diseases such as AD and MS.