Levels have been shown to decrease significantly in chronic diseases with inflammation.29Decorin infusion prevented brain damage by showing an anti-inflammatory effect in rats with hydrocephalus.30Özay et al. showed that decorin inactivates transforming growth factor β1 and protects the brain tissue and neuronal cells after traumatic brain injury.31Intracranial hypertension is also a disease in which neuronal damage and inflammation are clearly observed, and we found that CSF decorin level was significantly low in the patient group. Here, DCN is linked to hypertensive disorder.