Interleukin-33 participates in Th2-associated immune reactions.37It is expressed in specific regions of the brain and the spinal cord and mediates the interaction between immune, endothelial and CNS resident cells.38Interleukin-33 is activate inflammatory cells, including glial cells also it is involved in the neuroinflammation of many neurological diseases such as AD and MS. This evidence concerns the gene IL33 and Alzheimer disease.