The Nsp1-mediated host shutoff plays a key role in suppressing innate immune responses in infected cells, which has been demonstrated by comparing wild-type and recombinant Nsp1 mutant CoV infections with transmissible gastroenteritis virus (TGEV) [42], mouse hepatitis virus (MHV) [43], MERS-CoV [44], SARS [45], and CoV2 [46]. The gene discussed is SH2D3A; the disease is infection.