Based on the UPS signature was established to predict MM survival according to the formula: risk score = (KCTD12 × 0.09469841) + (SIAH1 × 0.375796476) + (TRIM47 × 0.123243103) + (TRIM58 × 0.187060727) + (UBE2S × 0.22107747) + (UBE2T × 0.37637129). Here, TRIM58 is linked to Miyoshi myopathy.