TERT and neoplasm: Vedelek et al. (2020) found that TERT inactivation in large-bodied rodents such as beavers occurs without a GAPBA transcription factor, which plays a key role in TERT. The authors argue that TERT inactivation in these large rodent species strengthens the hypothesis of replicative senescence as a tumor suppressor mechanism (Vedelek et al., 2020).