TGFB1 and systemic sclerosis: Overexpression of TGF-β correlated with the formation and development of fibrosis, which supports the fact that TGF-β is related to fibrotic diseases, such as pulmonary fibrosis, hepatic fibrosis, renal fibrosis, cardiac fibrosis, and systemic sclerosis [7, 98, 99] (Fig. 4).