Regarding the inhibitory effect of entacapone on FTO we expected to observe significant increase in m6A as substrate of FTO, however unexpectedly our results showed a minor non‐significant increase in m6A of total RNA from entacapone treated ESCC (mean difference YM‐1 = +6 ng/ml and KYSE‐30 = +8 ng/mL). The gene discussed is FTO; the disease is esophageal squamous cell carcinoma.