Although overexpression of FTO demethylasehas been reported in esophagus tumor in associated with lower survival rate and poorer prognosis20; but overexpression of METTL3 methyl transferases,34 and ALKBH5 as another m6A demethylase35 is also reported to be associated with poor prognosis in esophageal tumors. Here, ALKBH5 is linked to neoplasm of esophagus.