CD4 and intracranial hemorrhage: In addition, FUS-induced cavitation of microbubbles still poses a risk of tissue injury and inflammatory response has been observed (e.g. infiltration, activation of CD4+ and CD8+ T cells, and cytotoxicity of Cytotoxic T lymphocytes), and brain hemorrhage (Aryal et al., 2014; Fan et al., 2014; van den Bijgaart et al., 2017).